A seemingly naive and devout young woman finds her way in the underground world of truck stop sex workers a.k.a. "lot lizards."

After robbing a pharmacy, a selfless woman and her mute friend kidnap a drug addict then hit the road to distribute the stolen "life saving" medication, but find themselves trapped in the fringe lands of a law-less and psychedelic city.

Utah (Jack Kilmer) and Opal (Alice Englert) are junkies living on the streets of rural Ohio until a seemingly chance encounter with the enigmatic Wood (Michael Kenneth Williams) brings them to Los Angeles for drug treatment. Utah appears to find sobriety with the help of treatment center shrink, Dr. White (Melissa Leo), and tech turned love interest, May (Jessica Rothe). They soon learn that drug treatment is but a cover for a predatory business, enlisting addicts to recruit other addicts. Utah...